HOW TO
DETECT EG/EoD
Diagnosis of eosinophilic gastritis and/or eosinophilic duodenitis (EG/EoD) can be STRAIGHTFORWARD WITH SYSTEMATIC COLLECTION OF BIOPSIES AND COUNTING OF MUCOSAL EOSINOPHILS1-4
DIAGNOSTIC PROTOCOLa,b
- Abbreviations: EGD, esophagogastroduodenoscopy; GI, gastrointestinal; hpf, high-power field.
- a Allakos does not provide medical advice and assumes no liability for medical care decisions made using this approach. Medical care decisions for individual patients are to be made by patients’ healthcare professionals, including decisions regarding diagnosing EG/EoD and how to evaluate biopsy samples.
- b Diagnostic algorithm based on recommendation of experts involved in prospective clinical studies of EG/EoD.
- c In 5 hpfs in the stomach and/or 3 hpfs in the duodenum.3,7,8
- d In the absence of other causes of eosinophilia (eg, infection).1
A diagnosis of EG/EoD can be easily missed without systematic biopsy and histopathology protocols6
The approach used in recent EG/EoD studies included the following steps:
- Take biopsies even if visually normal, as mucosae appear normal endoscopically in about half of all cases8
- During EGD, take at least 8 biopsies from the stomach and 4 from the duodenum, as eosinophilic inflammation is very patchy and can affect one or both regions3,6
- Request that your pathologist report gastric and/or duodenal eosinophil counts if ≥30/hpf, the accepted threshold for diagnosis of EG/EoD1-3
A diagnosis of EG/EoD can be easily missed without systematic biopsy and histopathology protocols6
The approach used in recent EG/EoD studies included the following steps:
- Take biopsies even if visually normal, as mucosae appear normal endoscopically in about half of all cases9
- During EGD, take at least 8 biopsies from the stomach and 4 from the duodenum, as eosinophilic inflammation is very patchy and can affect one or both regions4,6
- Request that your pathologist report gastric and/or duodenal eosinophil counts if ≥30 per hpf, the accepted threshold for diagnosis of EG/EoD1,3,8